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You don’t hear much talk about endocannabinoids in stoner circles, but they may be the key to unlocking the full potential of marijuana to treat depression.

Endocannabinoids are chemicals naturally produced in the brain, and they affect everything from our behavior and emotions to control our bodies. Scientists believe that stress can disrupt the brain’s ability to produce those crucial chemicals, and a deficit in endocannabinoids can potentially lead to depressive disorders.

As you’ve probably guessed, endocannabinoids are very similar in their makeup to cannabinoids like THC and CBD in pot, and they each bind to the same receptors. So, the thinking goes, smoking weed and ingesting those cannabinoids may help restore the endocannabinoid system to normal, thereby reducing or relieving depression symptoms.

That’s all theory at this point. But it’s backed up by the experience of users.